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Abstract
Preeclampsia remains a significant contributor to maternal morbidity and mortality, particularly in low-resource settings. This study assessed the awareness, incidence, and determinants of preeclampsia among pregnant women in rural Kisoro District, Uganda. A prospective cohort study design was employed. Data were collected from a cluster sample of 132 pregnant women attending antenatal clinics at three public owned primary health facilities in Kisoro. The data were analysed using descriptive and relative risk (RR) inferential statistics at 5% significance level and 95% confidence interval (CI). The study revealed inadequate awareness of preeclampsia (3.0%). The incidence rate of preeclampsia was observed to be 31.1%. Family history of hypertension increased the risk of having preeclampsia by 70% (RR: 1.7 (95% CI: 1.0-2.8); p = 0.03). In conclusion, the awareness of preeclampsia is inadequate, the burden is palpable, and the condition is determined by a family history of hypertension among pregnant women. Strict surveillance on pregnant women with family history of hypertension and more community enlightenment led by midwives are recommended.
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References
- Abate, B. A., Wordofa, M. A., & Dadhi, L. S. (2025). Knowledge of pregnant women towards pre-eclampsia in South Gondar zone. Scientific Reports, 15(1), 14676.
- Aduloju, O. P., Fajola, A., & Tuboteme, S. D. (2025). Prevalence, Risk Factors and Maternal-Fetal Outcomes of Hypertensive Disorders in Pregnancy: A 5-Year Retrospective Review at a Cottage Hospital in Rivers State, Nigeria. Sierra Leone Journal of Medicine, 2(1), 1-6.
- Ahmed, S., Brewer, A., Tsigas, E. Z., Rogers, C., Chappell, L., & Hewison, J. (2021). Women’s attitudes, beliefs and values about tests, and management for hypertensive disorders of pregnancy. BMC Pregnancy and Childbirth, 21(1), 665.
- Ayele, A. D., & Tilahun, Z. A. (2022). Determinants of pre-eclampsia among women attending delivery services in public health institutions of Debre Tabor Town: a case–control study. Reproductive Health, 19(1), 157.
- Awor, S., Byanyima, R., Abola, B., Nakimuli, A., Orach, C. G., Kiondo, P., ... & Kaye, D. (2022). Incidence of preeclampsia and retention to prenatal care in Northern Uganda. East African Medical Journal, 99(6). 4885.
- Bolarinwa, O. A. (2020). Sample size estimation for health and social science researchers: The principles and considerations for different study designs. Nigerian Postgraduate Medical Journal, 27(2), 67-75.
- Chang, K. J., Seow, K. M., & Chen, K. H. (2023). Preeclampsia: Recent advances in predicting, preventing, and managing the maternal and fetal life-threatening condition. International Journal of Environmental Research and Public Health, 20(4), 2994.
- Hu, R., Liang, Y., He, T., Zhou, Y., & Lv, Y. (2025). Causal association of hypertension in family members with preeclampsia-eclampsia in pregnant women: A two-sample Mendelian randomization study. Pregnancy Hypertension, 40, 101223.
- Jikamo, B., Adefris, M., Azale, T., & Alemu, K. (2023). Incidence, trends and risk factors of preeclampsia in sub-Saharan Africa: a systematic review and meta-analysis. PAMJ-One Health, 11(1), 39297.
- Kassa, B. G., Asnkew, S., Ayele, A. D., Nigussie, A. A., Demilew, B. C., & Mihirete, G. N. (2023). Preeclampsia and its determinants in Ethiopia: a systematic review and meta-analysis. PLoS One, 18(11), e0287038.
- Macassa, G. (2021). Social enterprise, population health and sustainable development goal 3: A public health viewpoint. Annals of Global Health, 87(1), 52.
- Nabulo, H., Ruzaaza, G., Mugabi, F., & Bajunirwe, F. (2021). Perceptions on preeclampsia and eclampsia among senior, older women, in rural Southwestern Uganda. Journal of Global Health Reports, 5, e2021009.
- Omar, WH., Fajardo, TY., Businge, J., Byamukama, O., Kayondo, M., Kato Kalyebara, P., ... & Tibaijuka, L. (2025). Association between hyperuricemia and adverse perinatal outcomes among women with preeclampsia at a tertiary hospital in Southwestern Uganda: a prospective cohort study. The Journal of Maternal-Fetal & Neonatal Medicine, 38(1), 2496394.
- Reddy, M., Fenn, S., Rolnik, D. L., Mol, B. W., da Silva Costa, F., Wallace, E. M., & Palmer, K. R. (2021). The impact of the definition of preeclampsia on disease diagnosis and outcomes: a retrospective cohort study. American Journal of Obstetrics and Gynecology, 224(2), 217.
- Shrateh, O. N., Al Khateeb, J., Habib, A., Kateeb, S., Khdour, H., Said, T., & Qawasmeh, A. (2025). Awareness and knowledge of preeclampsia among women in Palestine. Pregnancy Hypertension, 41, 101238.
References
Abate, B. A., Wordofa, M. A., & Dadhi, L. S. (2025). Knowledge of pregnant women towards pre-eclampsia in South Gondar zone. Scientific Reports, 15(1), 14676.
Aduloju, O. P., Fajola, A., & Tuboteme, S. D. (2025). Prevalence, Risk Factors and Maternal-Fetal Outcomes of Hypertensive Disorders in Pregnancy: A 5-Year Retrospective Review at a Cottage Hospital in Rivers State, Nigeria. Sierra Leone Journal of Medicine, 2(1), 1-6.
Ahmed, S., Brewer, A., Tsigas, E. Z., Rogers, C., Chappell, L., & Hewison, J. (2021). Women’s attitudes, beliefs and values about tests, and management for hypertensive disorders of pregnancy. BMC Pregnancy and Childbirth, 21(1), 665.
Ayele, A. D., & Tilahun, Z. A. (2022). Determinants of pre-eclampsia among women attending delivery services in public health institutions of Debre Tabor Town: a case–control study. Reproductive Health, 19(1), 157.
Awor, S., Byanyima, R., Abola, B., Nakimuli, A., Orach, C. G., Kiondo, P., ... & Kaye, D. (2022). Incidence of preeclampsia and retention to prenatal care in Northern Uganda. East African Medical Journal, 99(6). 4885.
Bolarinwa, O. A. (2020). Sample size estimation for health and social science researchers: The principles and considerations for different study designs. Nigerian Postgraduate Medical Journal, 27(2), 67-75.
Chang, K. J., Seow, K. M., & Chen, K. H. (2023). Preeclampsia: Recent advances in predicting, preventing, and managing the maternal and fetal life-threatening condition. International Journal of Environmental Research and Public Health, 20(4), 2994.
Hu, R., Liang, Y., He, T., Zhou, Y., & Lv, Y. (2025). Causal association of hypertension in family members with preeclampsia-eclampsia in pregnant women: A two-sample Mendelian randomization study. Pregnancy Hypertension, 40, 101223.
Jikamo, B., Adefris, M., Azale, T., & Alemu, K. (2023). Incidence, trends and risk factors of preeclampsia in sub-Saharan Africa: a systematic review and meta-analysis. PAMJ-One Health, 11(1), 39297.
Kassa, B. G., Asnkew, S., Ayele, A. D., Nigussie, A. A., Demilew, B. C., & Mihirete, G. N. (2023). Preeclampsia and its determinants in Ethiopia: a systematic review and meta-analysis. PLoS One, 18(11), e0287038.
Macassa, G. (2021). Social enterprise, population health and sustainable development goal 3: A public health viewpoint. Annals of Global Health, 87(1), 52.
Nabulo, H., Ruzaaza, G., Mugabi, F., & Bajunirwe, F. (2021). Perceptions on preeclampsia and eclampsia among senior, older women, in rural Southwestern Uganda. Journal of Global Health Reports, 5, e2021009.
Omar, WH., Fajardo, TY., Businge, J., Byamukama, O., Kayondo, M., Kato Kalyebara, P., ... & Tibaijuka, L. (2025). Association between hyperuricemia and adverse perinatal outcomes among women with preeclampsia at a tertiary hospital in Southwestern Uganda: a prospective cohort study. The Journal of Maternal-Fetal & Neonatal Medicine, 38(1), 2496394.
Reddy, M., Fenn, S., Rolnik, D. L., Mol, B. W., da Silva Costa, F., Wallace, E. M., & Palmer, K. R. (2021). The impact of the definition of preeclampsia on disease diagnosis and outcomes: a retrospective cohort study. American Journal of Obstetrics and Gynecology, 224(2), 217.
Shrateh, O. N., Al Khateeb, J., Habib, A., Kateeb, S., Khdour, H., Said, T., & Qawasmeh, A. (2025). Awareness and knowledge of preeclampsia among women in Palestine. Pregnancy Hypertension, 41, 101238.
